Liposomal mitomycin C prodrug (Promitil) compared to mitomycin C in chemoradiotherapy in preclinical models of colorectal cancer

被引：0
|
作者：
Tian, Xi
Minh Nguyen
Ohana, Patricia
Gabizon, Alberto A.
Wang, Andrew
机构：
[1] Univ N Carolina, Chapel Hill, NC USA
[2] Lipomedix Pharmaceut Ltd, Jerusalem, Israel
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 15期
关键词：
D O I：
10.1200/jco.2015.33.15_suppl.e13525
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
e13525
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy
    Tian, Xi
    Warner, Samuel B.
    Wagner, Kyle T.
    Caster, Joseph M.
    Zhang, Tian
    Ohana, Patricia
    Gabizon, Alberto A.
    Wang, Andrew Z.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 96 (03): : 547 - 555
  • [2] Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of a Mitomycin C Prodrug, for Use in Chemoradiation Therapy
    Tian, X.
    Caster, J. M.
    Warner, S. B.
    Wagner, K. T.
    Ohana, P.
    Gabizon, A.
    Wang, A. Z.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 96 (02): : S18 - S19
  • [3] LIPOSOMAL PRODRUG OF MITOMYCIN C WITH THIOLYTIC ACTIVATION: IMPROVED THERAPEUTIC INDEX OVER MITOMYCIN C IN PRECLINICAL STUDIES
    Gabizon, A. A.
    Amitay, Y.
    Shmeeda, H.
    Zalipsky, S.
    ANNALS OF ONCOLOGY, 2012, 23 : 164 - 165
  • [4] Chemo-Radiotherapy of Oligometastases of Colorectal Cancer With Pegylated Liposomal Mitomycin-C Prodrug (Promitil): Mechanistic Basis and Preliminary Clinical Experience
    Tahover, Esther
    Bar-Shalom, Rachel
    Sapir, Eli
    Pfeffer, Raphael
    Nemirovsky, Igor
    Turner, Yehonatan
    Gips, Maya
    Ohana, Patricia
    Corn, Benjamin W.
    Wang, Andrew Z.
    Gabizon, Alberto A.
    FRONTIERS IN ONCOLOGY, 2018, 8
  • [5] Preclinical Evaluation of Promitil, A Novel Nanoparticle Formulation of Mitomycin C, in Chemoradiation Therapy
    Tian, X.
    Nabeel, H.
    Wagner, K. T.
    Nguyen, M.
    Min, Y.
    Sethi, M.
    Wang, A. Z.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 90 : S803 - S803
  • [6] Development of Promitil®, a lipidic prodrug of mitomycin c in PEGylated liposomes: From bench to bedside
    Gabizon, Alberto
    Shmeeda, Hilary
    Tahover, Esther
    Kornev, Gleb
    Patil, Yogita
    Amitay, Yasmine
    Ohana, Patricia
    Sapir, Eli
    Zalipsky, Samuel
    ADVANCED DRUG DELIVERY REVIEWS, 2020, 154 (154-155) : 13 - 26
  • [7] Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients
    Golan, Talia
    Grenader, Tal
    Ohana, Patricia
    Amitay, Yasmine
    Shmeeda, Hilary
    La-Beck, Ninh M.
    Tahover, Esther
    Berger, Raanan
    Gabizon, Alberto A.
    CANCER MEDICINE, 2015, 4 (10): : 1472 - 1483
  • [8] Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer
    Lev, Avital
    Deihimi, Safoora
    Shagisultanova, Elena
    Xiu, Joanne
    Lulla, Amriti R.
    Dicker, David T.
    El-Deiry, Wafik S.
    CANCER BIOLOGY & THERAPY, 2017, 18 (09) : 694 - 704
  • [9] Ex-vivo activation of a liposomal prodrug of mitomycin C by human tumors
    Shira Dorot
    James Tankel
    Victoria Doviner
    Hilary Shmeeda
    Yasmine Amitay
    Patricia Ohana
    Amir Dagan
    Menachem Ben-Haim
    Petachia Reissman
    Alberto Gabizon
    Cancer Chemotherapy and Pharmacology, 2022, 90 : 109 - 114
  • [10] Ex-vivo activation of a liposomal prodrug of mitomycin C by human tumors
    Dorot, Shira
    Tankel, James
    Doviner, Victoria
    Shmeeda, Hilary
    Amitay, Yasmine
    Ohana, Patricia
    Dagan, Amir
    Ben-Haim, Menachem
    Reissman, Petachia
    Gabizon, Alberto
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2022, 90 (02) : 109 - 114
12345