Case Report of a Successful Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia and MRSA/Vancomycin-Resistant Enterococcus faecium Cholecystitis by Daptomycin

被引：18
|
作者：
Tascini, Carlo [2 ]
Di Paolo, Antonello [1 ]
Polillo, Marialuisa [1 ]
Ferrari, Mauro [3 ]
Lambelet, Paola [4 ]
Danesi, Romano [1 ]
Menichetti, Francesco [2 ]
机构：
[1] Univ Pisa, Div Pharmacol, Dept Internal Med, I-56126 Pisa, Italy
[2] Santa Chiara Univ Hosp, Infect Dis Unit, Pisa, Italy
[3] Univ Pisa, Div Vasc Surg, Dept Oncol Transplants & New Technol Med, I-56126 Pisa, Italy
[4] Versilia Hosp, Div Med, Camaiore, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 05期
关键词：
GRAM-POSITIVE INFECTIONS; PHARMACOKINETICS; PENETRATION;
D O I：
10.1128/AAC.01774-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A 72-year-old man, receiving 8 mg daptomycin/kg body weight/day for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, was diagnosed with MRSA/vancomycin-resistant Enterococcus faecium (VRE) cholecystitis (daptomycin MIC values, 1 and 2 mg/liter, respectively). After the fifth drug dose, the bile concentration of daptomycin was 66 mg/liter 5 min after drug administration, with the biliary concentration/MIC values higher than 30 for both bacterial strains. Therefore, daptomycin achieved therapeutic levels in bile, hence suggesting a role for the drug in the treatment of MRSA/VRE cholecystitis.
引用
收藏
页码：2458 / 2459
页数：2
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