Advances in metal-carbene complexes as potent anti-cancer agents

被引：262

作者：

Gautier, Arnaud ^{[1
,2
]}

Cisnetti, Federico ^{[2
]}

机构：

[1] CNRS, UMR 6504, F-63177 Aubiere, France

[2] Univ Blaise Pascal, Clermont Univ, Lab SEESIB, F-63000 Clermont Ferrand, France

来源：

METALLOMICS | 2012年 / 4卷 / 01期

关键词：

N-HETEROCYCLIC CARBENE; COORDINATED GOLD COMPOUND; IN-VITRO; ANTITUMOR-ACTIVITY; CLIP-PHEN; PHASE-I; CYTOTOXICITY; PALLADIUM; RUTHENIUM; VIVO;

D O I：

10.1039/c1mt00123j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This critical review is an updated survey of metal-carbenes as potential anticancer chemotherapeutics. We report on the recent advances in the discovery of N-heterocyclic carbenes, acyclic diamino carbenes and abnormal NHCs associated with metals from groups 10 and 11 that displayed antiproliferative activity and emphasize, when possible, their molecular target(s) and their mechanism of action.

引用

页码：23 / 32

页数：10

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