Attractor dynamics in the hippocampal representation of the local environment

被引:418
|
作者
Wills, TJ
Lever, C
Cacucci, F
Burgess, N
O'Keefe, J
机构
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
[2] UCL, Inst Cognit Neurosci, London WC1E 6BT, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1126/science.1108905
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Memories are thought to be attractor states of neuronal representations, with the hippocampus a likely substrate for context-dependent episodic memories. However, such states have not been directly observed. For example, the hippocampal place cell representation of location was previously found to respond continuously to changes in environmental shape alone. We report that exposure to novel square and circular environments made of different materials creates attractor representations for both shapes: Place cells abruptly and simultaneously switch between representations as environmental shape changes incrementally. This enables study of attractor dynamics in a cognitive representation and may correspond to the formation of distinct contexts in context-dependent memory.
引用
收藏
页码:873 / 876
页数:4
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