Effects of gabapentin on anxiety induced by simulated public speaking

被引：0
|
作者：
de-Paris, F
Sant'Anna, MK
Vianna, MRM
Barichello, T
Busnello, JV
Kapczinski, F
Quevedo, J [1 ]
Izquierdo, I
机构：
[1] Univ Extremo Sul Catarinense, Lab Neurotoxicol, BR-88806000 Criciuma, SC, Brazil
[2] Univ Fed Rio Grande Sul, Ctr Memoria, Dept Bioquim, Inst Ciencias Basicas Saude, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande Sul, Grp Psicofarmacol, Dept Psiquiatria, Fac Med, Porto Alegre, RS, Brazil
来源：
JOURNAL OF PSYCHOPHARMACOLOGY | 2003年 / 17卷 / 02期
关键词：
anxiety; jabapentin; simulated public speaking;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
,The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue. Mood Scale (VAMS) and Profile of Mood State (POMS)], during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with-gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.
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收藏
页码：184 / 188
页数：5
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