DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

被引：357
|
作者：
Lee, Jennifer [1 ]
Zhou, Pengbo [1 ]
机构：
[1] Cornell Univ, Dept Pathol & Lab Med, Weill Med Coll, New York, NY 10021 USA
来源：
MOLECULAR CELL | 2007年 / 26卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.molcel.2007.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of DDB1 and CUL4-associated factors (DCAFs) as substrate receptors, implicating a broad spectrum of cellular processes regulated by CUL4-DDB1.
引用
收藏
页码：775 / 780
页数：6
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