Dietary inflammatory index and osteoporosis: the National Health and Nutrition Examination Survey, 2017-2018

Purpose The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory effects of nutrients and foods. Inflammation may affect bone health. The purpose of this study was to explore the relationships of DII with bone mineral density (BMD) and osteoporosis. Methods This study involved 1023 women and 1080 men (age >= 50) in the US National Health and Nutrition Survey (NHANES), 2017-2018. Multivariable linear regression models were used to estimate the associations between DII and BMD. Association between DII and osteoporosis was tested with multivariable logistic regression models. Results In women, DII was negatively associated with total hip and femoral neck BMD after adjusting for covariates (P < 0.05). In men, DII was negatively associated with lumbar spine BMD (P < 0.05). DII was positively associated with osteoporosis in women (P < 0.05). The odds ratios (ORs) (95% CI) for osteoporosis associated with DII quartiles 2, 3 and 4 vs. quartile 1 were 2.95 (1.08, 8.09), 5.63 (2.87, 11.04), and 6.14(2.55, 14.78), respectively. No significant association was observed in men. Conclusions Higher DII scores were associated with increase osteoporosis risk in women, while no association was found in men. Greater pro-inflammatory diets might be associated with lower BMD in both women and men.