LDL-Cholesterol: From the Hypothesis to Causality

被引：6
|
作者：
Custodis, Florian [1 ]
Laufs, Ulrich [1 ]
机构：
[1] Univ Klinikum Saarlandes, Abt Innere Med Kardiol Angiol & Internist Intensi, Homburg, Germany
来源：
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2015年 / 140卷 / 10期
关键词：
LDL; Cholesterol; LDL-Hypothesis; IMPROVE-IT; CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; IMPROVE-IT; TRIALS; RISK; HYPERCHOLESTEROLEMIA; METAANALYSIS; SIMVASTATIN; PREVENTION; REDUCTION;
D O I：
10.1055/s-0041-102254
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The term "LDL-Hypothesis is frequently used to describe the association between LDL cholesterol (LDL-C) and cardiovascular outcomes. In the light of recent results of randomized trials the question arises whether the term hypothesis is still adequate. Considering the causal importance of LDL for the pathogenesis of atherosclerosis, epidemiological evidence and the clear genetic association of LDL-C with cardiovascular risk as well as the large statin trials and the reduction of events by a non-statin intervention in the IMPROVE-IT study, the term hypothesis appears to be outdated and should be replaced by LDL-causality.
引用
收藏
页码：761 / U71
页数：5
相关论文
共 50 条
  • [1] Evaluation of two automated direct LDL-cholesterol assays: the Cobas Integra LDL-cholesterol and EZ LDL-cholesterol methods.
    Lim, P
    Omar, A
    Sethi, S
    Aw, TC
    CLINICAL CHEMISTRY, 2000, 46 (06) : A100 - A100
  • [2] LDL-Cholesterol is the King
    Goumas, Georgios S.
    ANGIOLOGY, 2009, 60 (03) : 387 - 388
  • [3] SHOULD DIRECT LDL-CHOLESTEROL ASSAYS REPLACE THE FRIEDEWALD CALCULATED LDL-CHOLESTEROL?
    Faas, F.
    Spencer, H.
    ATHEROSCLEROSIS SUPPLEMENTS, 2009, 10 (02)
  • [4] SMALL DENSE LDL-CHOLESTEROL IS SUPERIOR TO LDL-CHOLESTEROL FOR DETERMINING SEVERE CORONARY ATHEROSCLEROSIS
    Meguro, Y.
    Ito, Y.
    Koba, S.
    Yokota, Y.
    Hirano, T.
    Ban, Y.
    Tsunoda, F.
    Sato, T.
    Shoji, M.
    Suzuki, H.
    Geshi, E.
    Kobayashi, Y.
    Katagiri, T.
    ATHEROSCLEROSIS SUPPLEMENTS, 2011, 12 (01) : 109 - 110
  • [5] LDL-cholesterol: The lower the better
    Pedro-Botet, Juan
    Pinto, Xavier
    CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS, 2019, 31 : 16 - 27
  • [6] IS IT NECESSARY TO CALCULATE LDL-CHOLESTEROL
    DRYGAS, J
    OSBURG, K
    JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, 1980, 18 (10): : 751 - 751
  • [7] Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways
    Wang, MingwDong
    Kiss, Robert S.
    Franklin, Vivian
    McBride, Heidi M.
    Whitman, Stewart C.
    Marcel, Yves L.
    JOURNAL OF LIPID RESEARCH, 2007, 48 (03) : 633 - 645
  • [8] LDL-CHOLESTEROL AND HDL-CHOLESTEROL IN CHILDREN
    SPAHN, U
    PLENERT, W
    PETRICH, E
    PEDIATRIC RESEARCH, 1981, 15 (08) : 1199 - 1199
  • [9] Cardiovascular mortality after intensive LDL-Cholesterol lowering: Does baseline LDL-Cholesterol really matter?
    Khan, Safi U.
    Michos, Erin D.
    AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2020, 1
  • [10] Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population
    Wadhwa, Nishtha
    Krishnaswamy, Radhika
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (12) : BC11 - BC13
12345