Role of Mitophagy in Cardiovascular Disease

被引：53

作者：

Yang, Yibo ^{[1
]}

Li, Tianyi ^{[1
]}

Li, Zhibo ^{[1
]}

Liu, Ning ^{[1
]}

Yan, Youyou ^{[1
]}

Liu, Bin ^{[1
]}

机构：

[1] Second Hosp Jilin Univ, Dept Cardiol, 218 Zigiang Rd, Changchun 130041, Peoples R China

来源：

AGING AND DISEASE | 2020年 / 11卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cardiomyocyte; cardiovascular disease; mitochondria; mitophagy; MITOCHONDRIAL QUALITY-CONTROL; CARDIAC ISCHEMIA/REPERFUSION INJURY; FOCAL CEREBRAL-ISCHEMIA; ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS; BRAIN-INJURY; CELL-DEATH; PINK1/PARKIN-MEDIATED MITOPHAGY; PLASMINOGEN-ACTIVATOR; REPERFUSION INJURY;

D O I：

10.14336/AD.2019.0518

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structure and function, and maintains cell survival and growth. Numerous recent studies have reported that mitophagy plays an important role in the pathogenesis of various cardiovascular diseases. This review summarizes the mechanisms underlying mitophagy and advancements in studies on the role of mitophagy in cardiovascular disease.

引用

页码：419 / 437

页数：19

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