Siloxane-based cross-coupling of bromopyridine derivatives: Studies for the synthesis of streptonigrin and lavendamycin

被引：39
|
作者：
McElroy, WT [1 ]
DeShong, P [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 25期
关键词：
D O I：
10.1021/ol0357503
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Highly functionalized 4-bromopyridines were prepared and found to undergo fluoride-promoted, Pd-catalyzed cross-coupling with aryltrialkoxysilanes to give sterically demanding biaryls. The 3-nitro-4-bromopyridine derivative coupled in good yield with TBAT (tetrabutylammonium triphenyidifluorosilicate) to provide a biaryl adduct that serves as a model system for the total synthesis of the antitumor antibiotics streptonigrin and lavendamycin.
引用
收藏
页码：4779 / 4782
页数：4
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