Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion

被引：26
|
作者：
Zhang, ZJ [1 ]
Ren, Q
Yang, H
Conrad, MN
Guacci, V
Kateneva, A
Dresser, ME
机构：
[1] Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA
[2] Oklahoma Med Res Fdn, Program Mol Cell & Dev Biol, Oklahoma City, OK 73104 USA
[3] Fox Chase Canc Ctr, Div Basic Sci, Philadelphia, PA 19111 USA
来源：
MOLECULAR MICROBIOLOGY | 2005年 / 56卷 / 03期
关键词：
D O I：
10.1111/j.1365-2958.2005.04582.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Budding yeast PDS5 is an essential gene in mitosis and is required for chromosome condensation and sister chromatid cohesion. Here we report that PDS also is required in meiosis. Pds5p localizes on chromosomes at all stages during meiotic cycle, except anaphase I. PDS5 plays an important role at first meiotic prophase. Failure in function of PDS5 causes premature separation of chromosomes. The loading of Pds5p onto chromosome requires the function of REC8, but the association of Rec8p with chromosome is independent of PDS5. Mutant analysis and live cell imaging indicate that PDS5 play a role in meiosis II as well.
引用
收藏
页码：670 / 680
页数：11
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