Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

被引：23

作者：

Lee, Nai-Lun ^{[1
,2
]}

Su, Jui-Hsin ^{[1
,2
]}

机构：

[1] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[2] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

来源：

MARINE DRUGS | 2011年 / 9卷 / 12期

关键词：

soft coral; Lobophytum crassum; cembranoids; OCTOCORAL BRIAREUM-EXCAVATUM; TUMOR-CELL-LINES; SARCOPHYTON-TROCHELIOPHORUM; OXYGENATED CEMBRANOIDS; DITERPENOIDS; BRIARANES; 12-HYDROXYBRIARANES; GIBBEROSA; DISCOVERY; ASSAY;

D O I：

10.3390/md9122526

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new cembranoids, culobophylins A-C (1-3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.

引用

页码：2526 / 2536

页数：11

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