Effects of Different Intensity Aerobic Exercise on Circulating levels of Neurotrophic Factor in Healthy and Hyperlipidemic Adults in a Local Population

Objective: The present study was to compare the pre and post serum brain derived neurotrophic factor (BDNF) levels in healthy and hyperlipidemic population at baseline and post 12 weeks of exercise and to correlate the pre and post serum BDNF levels in healthy and hyperlipidemic population at baseline and post 12 weeks of exercise. Methods: Two arm follow up non-blinded randomized controlled trial (RCT) conducted at Physiology department, Basic Medical Sceines Institute. A total 258 participants of any age were divided into two groups: 129 participants in one of the two groups, Group-1 adult hyperlipidemic group and Group-2 healthy adults' group. Both groups were additionally divided into 3 subgroups with different exercise intensity i.e., light, moderate and high intensity exercise. To evaluate the health status of participants, graded exercise test by using Bruce protocol and the HRmax was performed and given a specific exercise program for 12 weeks. The test was a conducted as per Bruce protocol 25 using a treadmill with heart rate monitoring and ECG monitor. Blood sample had been taken for the analysis of total cholesterol and serum levels of BDNF. Results: Mean levels of brain derived neurotropic factor (BDNF) of healthy and hyperlipidemic participants in all three different intensity exercise group (A, B, and C) at baseline and three follow-ups shown no statistically significant (p>0.05) difference inlight intensity exercise group (LIEG) on BDNF level from baseline (day zero) till three consecutive follow-ups. While, in moderate and high intensity participants significant (p<0.05) and highly significant (p<0.01) increase in BDNF levels respectively were demonstrated from day 0 to day 90. Conclusion: In light of our findings, we conclude that 12 weeks of moderate to high intensity exerciseprogress cognitive function, serum BDNF levels, and improved lipid profile parameters, while low exercise showed no mean difference for