Metadherin regulates radioresistance in cervical cancer cells

被引：38
|
作者：
Zhao, Ying [1 ]
Moran, Meena S. [2 ]
Yang, Qifeng [3 ]
Liu, Qiao [4 ,5 ]
Yuan, Cunzhong [1 ]
Hong, Shuhui [6 ]
Kong, Beihua [1 ]
机构：
[1] Shandong Univ, Dept Obstet & Gynecol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[2] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA
[3] Shandong Univ, Dept Breast Surg, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[4] Shandong Univ, Inst Mol Med & Genet, Minist Educ, Sch Med, Jinan 250012, Shandong, Peoples R China
[5] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Sch Med, Jinan 250012, Shandong, Peoples R China
[6] Shandong Univ, Dept Obstet & Gynecol, Affiliated Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China
来源：
ONCOLOGY REPORTS | 2012年 / 27卷 / 05期
基金：
中国国家自然科学基金;
关键词：
metadherin; radiosensitivity; cell cycle; apoptosis; DNA double-strand breaks repair; ASTROCYTE ELEVATED GENE-1; STRAND BREAK REPAIR; RAPID SUBTRACTION HYBRIDIZATION; DNA-DAMAGE; CARCINOMA; PHOSPHORYLATION; EXPRESSION; RADIATION; AEG-1; RADIOTHERAPY;
D O I：
10.3892/or.2012.1692
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metadherin (MTDH) promotes cancer metastasis, chemoresistance, invasion and angiogenesis. Upregulation of MTDH is correlated with both progression and poor clinical outcome of many types of cancers; however, there is currently no information regarding the role of MTDH in radiation sensitivity. Here, we investigated the effects of MTDH on the radiosensitivity of cervical cancer cells using the Si Ha cell line. We discovered that cervical cancer cells in which MTDH was knocked down had significantly increased radiosensitivity as measured by a clonogenic assay. MTDH knockdown cells also had increased apoptosis and a decreased proportion of cells arrested in the G2 phase after radiation treatment. MTDH knockdown also weakened the repair of DNA double-strand breaks (DSBs) induced by radiation. These results indicate that MTDH affects the radiosensitivity of cervical cancer cells and that MTDH may be a novel target to improve cervical cancer radiation response.
引用
收藏
页码：1520 / 1526
页数：7
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