Hepatitis B virus and hepatocarcinogenesis

被引：26
|
作者：
Azam, Faisal [1 ]
Koulaouzidis, Anastasios [2 ]
机构：
[1] Glan Clwyd Gen Hosp, Dept Oncol, Bodelwyddan LL18 5UJ, Rhyl, Wales
[2] Bangor Hosp, Dept Gastroenterol, Bangor, Gwynedd, Wales
来源：
ANNALS OF HEPATOLOGY | 2008年 / 7卷 / 02期
关键词：
hepatitis B virus; carcinogenesis; X-proteins; liver; hepatitis B virus genome;
D O I：
10.1016/S1665-2681(19)31867-8
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the most important predictor of hepatocarcinogenesis in HB surface antigen positive patients. We reviewed the mechanism of hepatocarcinogenesis on molecular level with a special emphasis on the role of X-protein. Hepatitis B X-protein communicates with host targets and disturbs cellular functions including cell cycle regulation, apoptosis, signalling, transcriptional regulation, encoding of cytoskeleton, cell adhesion molecules, oncogenes and tumour suppressor genes.
引用
收藏
页码：125 / 129
页数：5
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