Expression of latent and replicative-infection genes of Epstein-Barr virus in macrophage

被引：34
|
作者：
Shimakage, M
Kimura, M
Yanoma, S
Ibe, M
Yokota, S
Tsujino, G
Kozuka, T
Dezawa, T
Tamura, S
Ohshima, A
Yutsudo, M
Hakura, A
机构：
[1] Osaka Natl Hosp, Clin Res Inst, Chuo Ku, Osaka 5400006, Japan
[2] Osaka Natl Hosp, Dept Pediat, Osaka, Japan
[3] Osaka Natl Hosp, Dept Dermatol, Osaka, Japan
[4] Kansai Shinkyu Coll, Dept Anat, Kumatori, Osaka, Japan
[5] Kanagawa Canc Ctr, Clin Res Inst, Yokohama, Kanagawa, Japan
[6] Yokohama City Univ, Sch Med, Dept Pediat, Yokohama, Kanagawa, Japan
[7] Wakayama Med Coll, Dept Pediat, Wakayama, Japan
[8] Wakayama Med Coll, Dept Otorhinolaryngol, Wakayama, Japan
[9] Wakayama Med Coll, Dept Pathol 1, Wakayama, Japan
[10] Osaka Univ, Microbial Dis Res Inst, Dept Tumor Virol, Osaka, Japan
来源：
ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 01期
关键词：
D O I：
10.1007/s007050050492
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Unlike other herpesviruses, Epstein-Barr virus (EBV) has not yet been shown to infect macrophages. Six macrophage cultures were isolated from normal and affected samples. Nested polymerase chain reaction revealed the existence of the EBV genome in all these macrophages. EBV latent genes expression in all cultures were detected by mRNA in situ hybridization and immunofluorescence staining. Some cultures also expressed EBV replicative-infection proteins, while in other cultures induction of these proteins was demonstrated. These findings are the first to show expression of several latent and replicative-infection genes of EBV in macrophages, indicating that EBV proliferates in macrophages.
引用
收藏
页码：157 / 166
页数：10
相关论文
共 50 条
  • [1] Expression of latent and replicative-infection genes of Epstein-Barr virus in macrophage
    M. Shimakage
    M. Kimura
    S. Yanoma
    M. Ibe
    S. Yokota
    G. Tsujino
    T. Kozuka
    T. Dezawa
    S. Tamura
    A. Ohshima
    M. Yutsudo
    A. Hakura
    Archives of Virology, 1999, 144 : 157 - 166
  • [2] Epstein-Barr virus latent and replicative gene expression in gastric carcinoma
    Selves, J
    Bibeau, F
    Brousset, P
    Meggetto, F
    Mazerolles, C
    Voigt, JJ
    Pradere, B
    Chiotasso, P
    Delsol, G
    HISTOPATHOLOGY, 1996, 28 (02) : 121 - 127
  • [3] Epstein-Barr virus latent genes
    Kang, Myung-Soo
    Kieff, Elliott
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2015, 47 : e131 - e131
  • [4] EPSTEIN-BARR VIRUS GENES IN LATENT GROWTH TRANSFORMING INFECTION
    KIEFF, E
    DAMBAUGH, T
    HENNESSY, K
    FENNEWALD, S
    WHANG, D
    HUMMEL, M
    ARSENAKIS, M
    ROIZMAN, B
    DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1985, 4 (02): : 183 - 183
  • [5] The expression and function of Epstein-Barr virus encoded latent genes
    Young, LS
    Dawson, CW
    Eliopoulos, AG
    JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 2000, 53 (05): : 238 - 247
  • [6] Epstein-Barr virus latent infection in vivo
    Steven, NM
    REVIEWS IN MEDICAL VIROLOGY, 1997, 7 (02) : 97 - 106
  • [7] Hydroa vacciniforme with latent Epstein-Barr virus infection
    Ohtsuka, T
    Okita, H
    Otsuka, S
    Yamakage, A
    Yamazaki, S
    BRITISH JOURNAL OF DERMATOLOGY, 2001, 145 (03) : 509 - 510
  • [8] Epstein-Barr virus and oncogenesis: from latent genes to tumours
    Young, LS
    Murray, PG
    ONCOGENE, 2003, 22 (33) : 5108 - 5121
  • [9] Human B cells on their route to latent infection - Early but transient expression of lytic genes of Epstein-Barr virus
    Kalla, Markus
    Hammerschmidt, Wolfgang
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2012, 91 (01) : 65 - 69
  • [10] Expression of Epstein-Barr virus encoded latent genes in nasal T cell lymphomas
    vanGorp, J
    Brink, A
    Oudejans, JJ
    vandenBrule, AJC
    vandenTweel, JG
    Jiwa, NM
    deBruin, PC
    Meijer, CJLM
    JOURNAL OF CLINICAL PATHOLOGY, 1996, 49 (01) : 72 - 76
12345