Loss of lamivudine resistance in a zidovudine and lamivudine dual-resistant HIV-1 isolate after discontinuation of in vitro lamivudine drug pressure

被引：0

作者：

Rusconi, S ^{[1
]}

De Pasquale, MP ^{[1
]}

Milazzo, L ^{[1
]}

Kurtagic, S ^{[1
]}

Bulgheroni, E ^{[1
]}

Citterio, P ^{[1
]}

Galazzi, M ^{[1
]}

Catamancio, SL ^{[1
]}

Galli, M ^{[1
]}

机构：

[1] Univ Milan, Osped Luigi Sacco, Ist Malattie Infett & Trop, I-20157 Milan, Italy

来源：

ANTIVIRAL THERAPY | 1998年 / 3卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We examined the in vitro phenotypic and genotypic profiles of an extensively passaged human immunodeficiency virus type 1 clinical isolate which has been selected for lamivudine resistance, with an M184V mutation in a zidovudine-resistant genetic background, and then cultured with zidovudine alone. Our passaging strategy led to a decrease in lamivudine IC50 values, which were comparable to those prior to lamivudine exposure, and the genotypic restoration of the wild-type sequence at codon 184 of reverse transcriptase.

引用

页码：203 / 207

页数：5

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