Glucose measurements in solutions using fiberoptic evanescent wave spectroscopy and tunable CO2 laser.

There is an interest in using infrared spectroscopy techniques for blood analysis, and in particular for glucose measurements. Glucose concentration in aqueous solutions were measured using fiberoptic evanescent wave spectroscopy. A new spectrometer consisting of tunable CO2 laser as the radiation source, and a silver halide fiber was built. Several solutions were measured for calibration with concentrations in the range of 70-2000 mg/dl. After the calibration, solution were measured and predicted according to the calibration parameters. The predicted concentrations were in agreement with the reference ones. The predicted errors for concentrations range up to 200 mg/dl, which is the clinical range, was less then 18 mg/dl (a relative error of about 12%). The AgClBr fibers are non-toxic and therefore This measurement can be carried out in real-time, for in-situ measurements of glucose in blood.