Cancer Therapy By Targeting Hypoxia-Inducible Factor-1

被引:42
|
作者
Li, Y. [2 ,3 ]
Ye, D. [1 ]
机构
[1] Huazhong Univ Sci & Technol, Inflammat Div, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
[3] Harvard Univ, Sch Med, Boston, MA 02215 USA
基金
中国国家自然科学基金;
关键词
Cancer; hypoxia-inducible factor-1; angiogenesis; Warburg effects; tumor microenvironment; therapy; ENDOTHELIAL-GROWTH-FACTOR; SMALL-MOLECULE INHIBITORS; ACTIVATED PROTEIN-KINASE; RENAL-CELL CARCINOMA; FACTOR; 1-ALPHA; TUMOR-GROWTH; TRANSCRIPTIONAL ACTIVITY; FACTOR EXPRESSION; GENE-EXPRESSION; ANTITUMOR-ACTIVITY;
D O I
10.2174/156800910793605857
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumors are invariably less well-oxygenated than the normal tissues from which they arise. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation, survival, glucose metabolism and migration. The expression, activity and stability of HIF-1 are not only induced in response to reduced oxygen availability but also modulated through PI-3K, MAPKs, autocrine signaling pathways, E3 ubiquitin ligases, and other regulators. The regulators and effects of HIF-1 in cancer have intensively provided us a new clue for the HIF-1 targeting anticancer therapy. This review evaluates the HIF-1 structure, the regulation mechanisms, the functions in cancer and corresponding anticancer strategies.
引用
收藏
页码:782 / 796
页数:15
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