Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
被引:42
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作者:
Li, Y.
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机构:
Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA 02215 USAHuazhong Univ Sci & Technol, Inflammat Div, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China
Li, Y.
[2
,3
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Ye, D.
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Huazhong Univ Sci & Technol, Inflammat Div, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Inflammat Div, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China
Ye, D.
[1
]
机构:
[1] Huazhong Univ Sci & Technol, Inflammat Div, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
Tumors are invariably less well-oxygenated than the normal tissues from which they arise. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation, survival, glucose metabolism and migration. The expression, activity and stability of HIF-1 are not only induced in response to reduced oxygen availability but also modulated through PI-3K, MAPKs, autocrine signaling pathways, E3 ubiquitin ligases, and other regulators. The regulators and effects of HIF-1 in cancer have intensively provided us a new clue for the HIF-1 targeting anticancer therapy. This review evaluates the HIF-1 structure, the regulation mechanisms, the functions in cancer and corresponding anticancer strategies.
机构:
Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China