Green Route for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones Using GO@Fe(ClO4)3 Nanocatalyst under Solvent-Free Conditions

An effective and environmentally benign methodology has been proposed for the synthesis of isoxazol-5(4H)-one derivatives using GO@Fe(ClO4)(3) nanocatalyst. The one-pot multicomponent reaction of aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate under solvent-free conditions at 100 degrees C afforded the corresponding 4-(arylmethylidene)-3-methyl-1,2-oxazol-5(4H)-ones in good to excellent yields. The developed new protocol is environmentally friendly as it is characterized by safety, atom efficiency, low cost, mild solvent-free conditions, minimal waste, catalyst recyclability, easy workup, and excellent functional group tolerance for the synthesis of structurally diverse isoxazole derivatives. All products were characterized by spectral and analytical methods. Also, some new compounds were synthesized.