Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus

被引：14

作者：

Wing, HJ ^{[1
]}

Goldman, SR ^{[1
]}

Ally, S ^{[1
]}

Goldberg, MB ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 02期

关键词：

D O I：

10.1128/IAI.73.2.1217-1220.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease 1csP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determinant of Shigella virulence.

引用

页码：1217 / 1220

页数：4

共 15 条

[1] YfiB: An Outer Membrane Protein Involved in the Virulence of Shigella flexneri
Sen, Tanuka
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[2] Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri
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MBIO, 2022, 13 (05):
[3] Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence
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[4] SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri
Egile, C
dHauteville, H
Parsot, C
Sansonetti, PJ
MOLECULAR MICROBIOLOGY, 1997, 23 (05) : 1063 - 1073
[5] A Shigella flexneri Virulence Plasmid Encoded Factor Controls Production of Outer Membrane Vesicles
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Benjamin, Jeremy
Ryu, Julie
Jarrar, Ameer
Garduno, Rafael
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[6] STUDIES ON VIRULENCE OF SHIGELLA-FLEXNERI - PROTECTIVE EFFECT OF OUTER-MEMBRANE PROTEINS
MULCZYK, M
ADAMUS, G
WITKOWSKA, D
ROMANOWSKA, E
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 1981, 29 (01) : 85 - 90
[7] Multicopy icsA is able to suppress the virulence defect caused by wzzSF mutation in the Shigella flexneri
Morona, R
Van Den Bosch, L
FEMS MICROBIOLOGY LETTERS, 2003, 221 (02) : 213 - 219
[8] Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP
Hensley, Christopher T.
Kamneva, Olga K.
Levy, Karen M.
Labahn, Stephanie K.
Africa, Lia A.
Wing, Helen J.
ARCHIVES OF MICROBIOLOGY, 2011, 193 (04) : 263 - 274
[9] Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP
Elizabeth Ngoc Hoa Tran
Attridge, Stephen R.
Min Yan Teh
Morona, Renato
FEMS MICROBIOLOGY LETTERS, 2015, 362 (12)
[10] Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP
Christopher T. Hensley
Olga K. Kamneva
Karen M. Levy
Stephanie K. Labahn
Lia A. Africa
Helen J. Wing
Archives of Microbiology, 2011, 193 : 263 - 274

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