In silico oncology: a top-down multiscale simulator of cancer dynamics. Studying the effect of symmetric stem cell division on the cellular constitution of a tumour

被引：0

作者：

Stamatakos, G. S. ^{[1
]}

Kolokotroni, E. ^{[1
]}

Dionysiou, D. ^{[1
]}

Georgiadi, E. ^{[1
]}

Giatili, S. ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Sch Elect & Comp Engn, Inst Commun & Comp Syst, Lab Microwaves & Fibre Opt,Silico Oncol Grp, GR-15773 Zografos, Greece

来源：

WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, VOL 25, PT 4: IMAGE PROCESSING, BIOSIGNAL PROCESSING, MODELLING AND SIMULATION, BIOMECHANICS | 2010年 / 25卷

关键词：

in silico cancer modelling; in silico oncology; oncosimulator; multiscale cancer modelling; top-down approach; GLIOBLASTOMA-MULTIFORME; MODEL; GROWTH; VIVO; RADIOTHERAPY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The tremendous rate of accumulation of experimentally and clinically extracted knowledge concerning cancer at all levels of biocomplexity dictates the development of integrative in silico models of tumour dynamics in order to better understand and treat the disease. Since the eventual translation of biomodels into clinical practice presupposes successful clinical validation we have developed a number of multiscale cancer simulation models oriented towards patient individualized treatment optimization. A top-down modelling approach based primarily on discrete event/state simulation has been proposed, developed and implemented. The emerging simulators have been serving as the core simulation modules (oncosimulators) of both the EC funded research projects Contra-Cancrum and ACGT. In this paper a brief outline of the basics of the approach along with paradigmal results demonstrating the effect of symmetric division of cancer stem cells on the cellular constitution of a tumour are presented. The potential and extensibility of the models are discussed.

引用

页码：1830 / 1833

页数：4