Assessment of the Field Utility of a Rapid Point-of-Care Test for SARS-CoV-2 Antibodies in a Household Cohort

被引：3

作者：

Churiwal, Mehal ^{[1
]}

Lin, Kelly D. ^{[1
]}

Khan, Salman ^{[2
]}

Chhetri, Srijana ^{[1
]}

Muller, Meredith S. ^{[1
]}

Tompkins, Kathleen ^{[1
]}

Smith, Judy ^{[1
]}

Litel, Christy ^{[1
]}

Whittelsey, Maureen ^{[1
]}

Basham, Christopher ^{[1
]}

Rapp, Tyler ^{[1
]}

Cerami, Carla ^{[1
,3
]}

Premkumar, Lakshmanane ^{[2
]}

Lin, Jessica T. ^{[1
]}

机构：

[1] Univ N Carolina, Inst Global Hlth & Infect Dis, Sch Med, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Sch Med, Chapel Hill, NC 27599 USA

[3] London Sch Hyg & Trop Med, MRC Unit Gambia, Fajara, Gambia

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2022年 / 106卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RECEPTOR-BINDING DOMAIN;

D O I：

10.4269/ajtmh.21-0592

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Point-of-care (POC) tests to detect SARS-CoV-2 antibodies offer quick assessment of serostatus after natural infection or vaccination. We compared the field performance of the BioMedomics COVID-19 IgM/IgG Rapid Antibody Test against an ELISA in 303 participants enrolled in a SARS-CoV-2 household cohort study. The rapid antibody test was easily implemented with consistent interpretation across 14 users in a variety of field settings. Compared with ELISA, detection of seroconversion lagged by 5 to 10 days. However, it retained a sensitivity of 90% (160/177, 95% confidence interval [CI] 85-94%) and specificity of 100% (43/43, 95% CI 92-100%) for those tested 3 to 5 weeks after symptom onset. Sensitivity was diminished among those with asymptomatic infection (74% [14/19], 95% CI 49-91%) and early in infection (45% [29/64], 95% CI 33-58%). When used appropriately, rapid antibody tests offer a convenient way to detect symptomatic infections during convalescence.

引用

页码：156 / 159

页数：4

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