Pharmacology of ionotropic glutamate receptors: A structural perspective

被引：51
|
作者：
Stawski, Philipp [1 ]
Janovjak, Harald [1 ]
Trauner, Dirk [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 22期
关键词：
Ionotropic glutamate receptors; AMPA receptors; Kainate receptors; NMDA receptors; Neurotransmitter; Clamshell; Agonist; Antagonist; Receptor desensitization; LIGAND-BINDING CORE; RETICULUM QUALITY-CONTROL; PARTIAL AGONIST ACTION; D-ASPARTATE RECEPTOR; GLUR2 AMPA RECEPTOR; CRYSTAL-STRUCTURES; ION CHANNELS; D-SERINE; ULTRASTRUCTURAL-LOCALIZATION; DESENSITIZATION KINETICS;
D O I：
10.1016/j.bmc.2010.09.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The impact of structural biology on the design of ligands (agonists, antagonists and modulators) for ionotropic glutamate receptors is reviewed. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：7759 / 7772
页数：14
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