Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease

被引：59

作者：

Gounder, Anshu P. ^{[1
,2
]}

Boon, Adrianus C. M. ^{[1
,2
,3
]}

机构：

[1] Washington Univ, Sch Med St Louis, Dept Internal Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med St Louis, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med St Louis, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

JOURNAL OF IMMUNOLOGY | 2019年 / 202卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CARNITINE PALMITOYLTRANSFERASE-II; QUANTITATIVE TRAIT LOCI; MOUSE-ADAPTED INFLUENZA; T-CELL REPERTOIRE; VIRUS-INFECTION; DENDRITIC CELLS; SEX-DIFFERENCES; RISK-FACTOR; AGED MICE; PREDISPOSING FACTOR;

D O I：

10.4049/jimmunol.1801010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza viruses continue to be a major global health threat. Severity and clinical outcome of influenza disease is determined by both viral and host factors. Viral factors have long been the subject of intense research and many molecular determinants have been identified. However, research into the host factors that protect or predispose to severe and fatal influenza A virus infections is lagging. The goal of this review is to highlight the recent insights into host determinants of influenza pathogenesis.

引用

页码：341 / 350

页数：10

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