NEDD4: The founding member of a family of ubiquitin-protein ligases

被引：118
|
作者：
Boase, Natasha Anne [1 ]
Kumar, Sharad [1 ]
机构：
[1] Univ S Australia, Ctr Canc Biol, Adelaide, SA 5001, Australia
来源：
GENE | 2015年 / 557卷 / 02期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Ubiquitin; Ubiquitin protein ligases; NEDD4; family; IGF signalling; PTEN; GROWTH-FACTOR RECEPTOR; FACTOR-I RECEPTOR; E3; LIGASE; WW DOMAIN; EPITHELIAL NA+; C2; DOMAIN; MEDIATED DEGRADATION; FUNCTIONAL DIVERSITY; TUMOR-SUPPRESSOR; IRON HOMEOSTASIS;
D O I：
10.1016/j.gene.2014.12.020
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the pathophysiological significance of this important ubiquitin ligase. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：113 / 122
页数：10
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