Preferential solvation and hydrogen bonding in mixed solvents

被引：44
|
作者：
Cook, Joanne L. [1 ]
Hunter, Christopher A. [1 ]
Low, Caroline M. R. [2 ]
Perez-Velasco, Alejandro [1 ]
Vinter, Jeremy G. [3 ]
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Univ London Imperial Coll Sci Technol & Med, Drug Discovery Facil, London SW7 2AY, England
[3] Cresset Biomol Discovery, Letchworth SG6 4ET, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 33期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
hydrogen bonds; molecular recognition; NMR spectroscopy; solvation; solvent mixtures;
D O I：
10.1002/anie.200801349
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Oak trees from acorns: A small amount (< 1%) of a cosolvent can change the stability of the H-bonded complex on the right-hand side of the equation by an order of magnitude. Mixtures of chloroform and THF were found to be more polar than either of the pure solvents by using this complex as a molecular-recognition probe of solvation. A quantitative interpretation based on preferential solvation accounts for the properties of solvent mixtures. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：6275 / 6277
页数：3
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