Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis

被引:29
|
作者
Suzumori, N [1 ]
Katano, K [1 ]
Suzumori, K [1 ]
机构
[1] Nagoya City Univ, Grad Sch Med, Dept Obstet & Gynecol, Mizuho Ku, Nagoya, Aichi 4678601, Japan
关键词
angiogenesis; chemokine; ENA-78; neovascularization; peritoneal fluid;
D O I
10.1016/j.fertnstert.2003.08.011
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To assess the release of epithelial neutrophil-activating peptide-78 (ENA-78) into peritoneal fluid in women with and without endometriosis. Design: Retrospective study. Setting: Nagoya City University Hospital. Patient(s): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) and without (n = 24) endometriosis. Intervention(s): Peritoneal fluid samples were obtained at laparotomy or laparoscopy. Main Outcome Measure(s): The ENA-78 concentrations in the peritoneal fluid were measured using enzyme-linked immunosorbent assay (ELISA). Result(s): The concentrations of ENA-78 in the peritoneal fluid were markedly elevated in the endometriosis patients as compared with the controls, especially in women with severe stage disease. Conclusion(s): We conclude that ENA-78 is an important factor that may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization. (C) 2004 by American Society for Reproductive Medicine.
引用
收藏
页码:305 / 308
页数:4
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