The role of genetic variation of BDNF gene in antidepressant-induced mania in bipolar disorder

被引：8
|
作者：
Ferreira, Alexandre de Aguiar [1 ]
Neves, Fernando Silva [2 ]
Garcia Santos Pimenta, Guilherme Jose [3 ]
Mello, Marina Pena [3 ]
Miranda, Debora Marques [3 ]
Romano-Silva, Marco Aurelio [1 ,3 ]
De Marco, Luiz Armando [4 ]
Correa, Humberto [1 ,2 ,3 ]
机构：
[1] Fed Univ Minas Gerais ICB UFMG, Neurosci Program, Inst Biol Sci, Belo Horizonte, MG, Brazil
[2] Fed Univ Minas Gerais ICB UFMG, Cellular Biol Program, Inst Biol Sci, Belo Horizonte, MG, Brazil
[3] Fed Univ Minas Gerais FM UFMG, Lab Neurosci, Dept Mental Hlth, Fac Med, Belo Horizonte, MG, Brazil
[4] Fed Univ Minas Gerais ICB UFMG, Dept Pharmacol, Inst Biol Sci, Belo Horizonte, MG, Brazil
来源：
PSYCHIATRY RESEARCH | 2010年 / 180卷 / 01期
关键词：
Brain-derived neurotrophic factor (BDNF) gene; Antidepressant induced mania; Bipolar disorder; NEUROTROPHIC FACTOR BDNF; FAMILY-BASED ASSOCIATION; MOOD DISORDERS; DEPRESSION; RECEPTOR; STRESS; MODEL;
D O I：
10.1016/j.psychres.2010.04.036
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The occurrence of mania during antidepressant treatment is a key issue in the clinical management of bipolar disorder (BD) Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of mood disorders Moreover antidepressants increase the expression of BDNF and its overactivity may be Involved in the mechanism of development of the manic state The aim of the present study was to test the influence of BDNF gene alterations in antidepressant induced mania in bipolar patients A case-control study was performed to analyse genotype and allele frequencies for the BDNF polymorphisms between two groups [37 patients with antidepressant-induced mania (AIM+) and 55 patients without antidepressant-induced mania (AIM-)] No significant differences were found between AIM+ and AIM- groups Our results did not support the BDNF gene link to antidepressant-induced mania like a previous study with a smaller sample has already suggested (C) 2010 Elsevier Ireland Ltd All rights reserved
引用
收藏
页码：54 / 56
页数：3
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