Palladium-Catalyzed Intramolecular Amidation of C(sp2)-H Bonds: Synthesis of 4-Aryl-2-quinolinones

被引：103
|
作者：
Inamoto, Kiyofumi [1 ]
Saito, Tadataka [1 ]
Hiroya, Kou [1 ]
Doi, Takayuki [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 11期
基金：
日本学术振兴会;
关键词：
C-H FUNCTIONALIZATION; CHANNEL OPENING RELAXANTS; DIRECT ARYLATION; AMINATION REACTION; DERIVATIVES; CONSTRUCTION; 2-QUINOLONES; CYCLIZATION; OXIDATION; ALKALOIDS;
D O I：
10.1021/jo100557s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalytic synthetic approach For the synthesis of nolinone compounds through a Pd-catalyzed C(sp(2))-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl2 and Cu(OAc)(2) under an O-2 atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.
引用
收藏
页码：3900 / 3903
页数：4
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