The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure

被引：4

作者：

Kang-Sickel, Juei-Chuan C. ^{[1
]}

Butler, Mary Ann ^{[2
]}

Frame, Lynn ^{[3
]}

Serdar, Berrin ^{[4
]}

Chao, Yi-Chun E. ^{[1
]}

Egeghy, Peter ^{[5
]}

Rappaport, Stephen M. ^{[6
]}

Toennis, Christine A. ^{[2
]}

Li, Wang ^{[7
]}

Borisova, Tatyana ^{[3
]}

French, John E. ^{[8
]}

Nylander-French, Leena A. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA

[2] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Lubbock, TX 79430 USA

[4] Univ Colorado Denver, Dept Environm & Occupat Hlth, Colorado Sch Publ Hlth, Aurora, CO USA

[5] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA

[6] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[7] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA

[8] Natl Inst Environm Hlth Sci, Host Susceptibil Branch, Natl Toxicol Program, Res Triangle Pk, NC USA

来源：

BIOMARKERS | 2011年 / 16卷 / 07期

关键词：

Biomarkers; CYP2E1; dermal exposure; glutathione S-transferase mu 1 (GSTM1); glutathione S-transferase theta 1 (GSTT1); jet fuel (JP-8); keratin adduct; NAD(P) H:quinone oxidoreductase (NQO1); 1-naphthol; 2-naphthol; naphthalene; urine; POLYCYCLIC AROMATIC-HYDROCARBONS; GENETIC POLYMORPHISMS; DERMAL EXPOSURE; IN-VITRO; NAPHTHALENE METABOLITES; MAINTENANCE WORKERS; URINARY BIOMARKERS; ALBUMIN ADDUCTS; FOUNDRY WORKERS; AIR-POLLUTION;

D O I：

10.3109/1354750X.2011.611598

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.

引用

页码：590 / 599

页数：10

共 12 条

[1] Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo
Kang-Sickel, Juei-Chuan C.
Stober, Vandy P.
French, John E.
Nylander-French, Leena A.
BIOMARKERS, 2010, 15 (06) : 488 - 497
[2] Cross hedging jet-fuel price exposure
Adams, Zeno
Gerner, Mathias
ENERGY ECONOMICS, 2012, 34 (05) : 1301 - 1309
[3] S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons
Kang-Sickel, Juei-Chuan C.
Fox, Donii D.
Nam, Tae-gyu
Jayaraj, Karupiah
Ball, Louise M.
French, John E.
Klapper, David G.
Gold, Avram
Nylander-French, Leena A.
CHEMICAL RESEARCH IN TOXICOLOGY, 2008, 21 (04) : 852 - 858
[4] Urinary biomarkers of exposure to jet fuel (JP-8)
Serdar, B
Egeghy, PP
Waidyanatha, S
Gibson, R
Rappaport, SM
ENVIRONMENTAL HEALTH PERSPECTIVES, 2003, 111 (14) : 1760 - 1764
[5] Urinary biomarkers of occupational jet fuel exposure among air force personnel
Smith, Kristen W.
Proctor, Susan P.
Ozonoff, A. L.
McClean, Michael D.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2012, 22 (01) : 35 - 45
[6] Urinary biomarkers of occupational jet fuel exposure among air force personnel
Kristen W Smith
Susan P Proctor
A L Ozonoff
Michael D McClean
Journal of Exposure Science & Environmental Epidemiology, 2012, 22 : 35 - 45
[7] Standardization of the tape-strip sample by determination of keratin in the sample after exposure to jet fuel.
Chao, Y
Nylander-French, LA
TOXICOLOGICAL SCIENCES, 2003, 72 : 338 - 339
[8] EVALUATION AND COMPARISON OF URINARY METABOLIC BIOMARKERS OF EXPOSURE FOR THE JET FUEL JP-8
B'Hymer, Clayton
Krieg, Edward, Jr.
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Toennis, Christine A.
Clark, John C.
Kesner, James S.
Gibson, Roger
Butler, Mary Ann
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2012, 75 (11): : 661 - 672
[9] Identification of biomarkers indicative of neurological effects due to jet fuel exposure in rats using mass spectrometric imaging
Schaffer, Forrest
Swanson, Matthew
Reich, Richard
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[10] Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel
Maule, Alexis L.
Proctor, Susan P.
Blount, Benjamin C.
Chambers, David M.
McClean, Michael D.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2016, 58 (01) : 24 - 29

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