Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

被引：7
|
作者：
Ziora, Zyta M. [1 ,2 ]
Wimmer, Norbert [1 ]
New, Roger [3 ]
Skwarczynski, Mariusz [1 ]
Toth, Istvan [1 ,2 ]
机构：
[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, CIPDD, Brisbane, Qld 4072, Australia
[3] Proxima Concepts Ltd, London Biosci Innovat Ctr, London NW1 0TU, England
来源：
CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 12期
基金：
澳大利亚研究理事会;
关键词：
Lipoamino acids; Glycolipopeptides; Self-assembly; Dynamic combinatorial library; Micellization; DYNAMIC COMBINATORIAL CHEMISTRY; CONFORMATIONAL-ANALYSIS; MODIFIED ENKEPHALINS; DELIVERY-SYSTEMS; ORAL ABSORPTION; IN-VITRO; AZIDES; IDENTIFICATION; LIBRARIES; SUGAR;
D O I：
10.1016/j.carres.2011.03.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1439 / 1444
页数：6
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