Hepatitis E virus and chronic hepatitis in organ-transplant recipients.

被引：988
|
作者：
Kamar, Nassim [1 ,2 ]
Selves, Janick [3 ]
Mansuy, Jean-Michel [4 ]
Ouezzani, Leila [1 ]
Peron, Jean-Marie [2 ,5 ]
Guitard, Joelle [1 ]
Cointault, Olivier [1 ]
Esposito, Laure [1 ]
Abravanel, Florence [4 ,6 ]
Danjoux, Marie [3 ]
Durand, Dominique [1 ]
Vinel, Jean-Pierre [5 ]
Izopet, Jacques [4 ,6 ]
Rostaing, Lionel [1 ,6 ]
机构：
[1] CHU Rangueil, Dept Nephrol Dialysis & Multiorgan Transplantat, F-31059 Toulouse 9, France
[2] CHU Rangueil, INSERM, Unite 858, IFR 31, F-31059 Toulouse, France
[3] CHU Purpan, Dept Histopathol, Toulouse, France
[4] CHU Purpan, Dept Virol, Toulouse, France
[5] CHU Purpan, Dept Hepatol, Toulouse, France
[6] CHU Purpan, INSERM, Unite 563, IFR 30, Toulouse, France
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 08期
关键词：
D O I：
10.1056/NEJMoa0706992
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed. Copyright © 2008 Massachusetts Medical Society.
引用
收藏
页码：811 / 817
页数：7
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