Protective immunization against Helicobacter stimulates long term immunity

被引：23
|
作者：
Radcliff, FJ
Chen, MH
Lee, A
机构：
[1] UNIV NEW S WALES, SCH MICROBIOL & IMMUNOL, SYDNEY, NSW 2052, AUSTRALIA
[2] SUN YATSEN UNIV MED SCI, AFFILIATED HOSP 1, GUANGZHOU, PEOPLES R CHINA
来源：
VACCINE | 1996年 / 14卷 / 08期
关键词：
H-felis mouse model; H-pylori; immunization; cholera toxin;
D O I：
10.1016/0264-410X(95)00246-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunization with an oral vaccine composed of whole cell sonicates of Helicobacter felis plus cholera toxin (CT) can protect mice from H. felis challenge. The aim of this study was to determine whether this protective immunity was long-lived. Mice were given the vaccine then left for up to 15 months before challenge. After 15 months, all mice were still protected from H. felis infection, indicating that oral immunization using bacterial antigens plus CT can stimulate long-term focal immunological memory. Copyright (C) 1996 Elsevier Science Ltd.
引用
收藏
页码：780 / 784
页数：5
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