Ultrastructural analysis of the interactions between Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica and human tracheal epithelial cells

被引：11
|
作者：
Gueirard, P
Bassinet, L
Bonne, I
Prevost, MC
Guiso, N
机构：
[1] Inst Pasteur, Unite Prevent & Therapie Mol Malad Humaines, F-75724 Paris 15, France
[2] Ctr Hosp Intercommunal Creteil, Serv Pneumol, Creteil, France
[3] Inst Pasteur, Plate Forme Microscopie Elect, F-75724 Paris 15, France
来源：
MICROBIAL PATHOGENESIS | 2005年 / 38卷 / 01期
关键词：
Bordetella; human respiratory epithelial cells; transmission electronic microscopy; cytotoxicity; uptake; intracellular survival;
D O I：
10.1016/j.micpath.2004.08.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bordetella pertussis. Bordetella parapertussis and Bordetella bronchiseptica are respiratory pathogens that colonize the respiratory tract of their host after adhesion to the respiratory epithelium. Presently, the intracellular fate of these bacteria in human tracheal epithelial cells was compared by use of transmission electron microscopy. The three species, even when cytotoxic, were taken-up by epithelial cells. Although. some intracellular bacteria appeared morphologically intact and survived a few days inside epithelial cells, most of them appeared quickly degraded, phenomenon which was associated with an intense cell metabolic activity. Even cytotoxic Bordetella species is ultimately killed by human epithelial cells. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：41 / 46
页数：6
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