Recent trends in metabolic engineering of microbial chemical factories

被引：78
|
作者：
Liu, Yi [1 ,2 ]
Nielsen, Jens [1 ,2 ,3 ]
机构：
[1] Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden
[2] Chalmers Univ Technol, Novo Nordisk Fdn, Ctr Biosustainabil, SE-41296 Gothenburg, Sweden
[3] Tech Univ Denmark, Ctr Biosustainabil, Novo Nordisk Fdn, DK-2800 Lyngby, Denmark
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2019年 / 60卷
关键词：
DE-NOVO PRODUCTION; SACCHAROMYCES-CEREVISIAE; FERMENTATIVE PRODUCTION; YEAST; BIOSYNTHESIS; BIOFUELS; PATHWAY; MICROORGANISMS; TOLERANCE; SECRETION;
D O I：
10.1016/j.copbio.2019.05.010
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Microbe-mediated chemical production can replace traditional fossil-dependent production and hereby ensure sustainable production of chemicals that are important for our society. Significant success in economical chemical bioproduction has been accomplished by improving the cellular properties of microbial cells through metabolic engineering. The emergence of new techniques and strategies has led to a significant reduction in the turnaround time in the classic design-buildtest-learn (DBTL) cycle in metabolic engineering. Here, we summarize the recent achievements and trends in microbial production of chemicals, with a focus on biofuels and high-value natural compounds. In addition, we offer perspectives on the challenges and opportunities for the successful establishment of future microbial chemical factories.
引用
收藏
页码：188 / 197
页数：10
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