Inhibitory stereochemistry of N-chloroacetyl-N-hydroxyleucine methyl ester for thermolysin

被引：3
|
作者：
Kim, DH [1 ]
Jin, YH [1 ]
机构：
[1] POHANG UNIV SCI & TECHNOL,DEPT CHEM,POHANG 790784,SOUTH KOREA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 02期
关键词：
D O I：
10.1016/0960-894X(95)00576-F
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The previously reported irreversible inhibition of thermolysin by (DL)-N-chloroacetyl-N-hydroxyleucine methyl ester, an active site directed inactivator, is found to be due to the D-enantiomer. Thus, while the D-enantiomer inactivated the enzyme, no inhibitory activity was found with the L-enantiomer. A possible explanation is presented for the reversed stereochemistry in the inactivation reaction compared with that of substrate.
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页码：153 / 156
页数：4
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