End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17

被引：48

作者：

Pebody, Richard ^{[1
]}

Warburton, Fiona ^{[1
]}

Ellis, Joanna ^{[1
]}

Andrews, Nick ^{[1
]}

Potts, Alison ^{[2
]}

Cottrell, Simon ^{[3
]}

Reynolds, Arlene ^{[2
]}

Gunson, Rory ^{[4
]}

Thompson, Catherine ^{[1
]}

Galiano, Monica ^{[1
]}

Robertson, Chris ^{[5
]}

Gallagher, Naomh ^{[6
]}

Sinnathamby, Mary ^{[1
]}

Yonova, Ivelina ^{[7
,8
]}

Correa, Ana ^{[7
]}

Moore, Catherine ^{[3
]}

Sartaj, Muhammad ^{[6
]}

de Lusignan, Simon ^{[7
,8
]}

McMenamin, Jim ^{[2
]}

Zambon, Maria ^{[1
]}

机构：

[1] Publ Hlth England, London, England

[2] Hlth Protect Scotland, Glasgow, Lanark, Scotland

[3] Publ Hlth Wales, Cardiff, S Glam, Wales

[4] West Scotland Specialist Virol Ctr, Glasgow, Lanark, Scotland

[5] Univ Strathclyde, Glasgow, Lanark, Scotland

[6] Publ Hlth Agcy Northern Ireland, Belfast, Antrim, North Ireland

[7] Univ Surrey, Guildford, Surrey, England

[8] Royal Coll Gen Practitioners, London, England

来源：

EUROSURVEILLANCE | 2017年 / 22卷 / 44期

关键词：

A(H1N1) PDM09 STRAIN; DECREASED EFFECTIVENESS; STATES; A(H3N2); CANADA;

D O I：

10.2807/1560-7917.ES.2017.22.44.17-00306

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The United Kingdom is in the fourth season of introducing a universal childhood influenza vaccine programme. The 2016/17 season saw early influenza A(H3N2) virus circulation with care home outbreaks and increased excess mortality particularly in those 65 years or older. Virus characterisation data indicated emergence of genetic clusters within the A(H3N2) C-3.2a group which the 2016/17 vaccine strain belonged to. Methods: The test-negative case-control (TNCC) design was used to estimate vaccine effectiveness (VE) against laboratory confirmed influenza in primary care. Results: Adjusted end-of-season vaccine effectiveness (aVE) estimates were 39.8% (95% confidence interval (CI): 23.1 to 52.8) against all influenza and 40.6% (95% CI: 19.0 to 56.3) in 18-64-year-olds, but no significant aVE in >= 65-year-olds. aVE was 65.8% (95% CI: 30.3 to 83.2) for 2-17-year-olds receiving quadrivalent live attenuated influenza vaccine. Discussion: The findings continue to provide support for the ongoing roll-out of the paediatric vaccine programme, with a need for ongoing evaluation. The importance of effective interventions to protect the >= 65-year-olds remains.

引用

页码：10 / 22

页数：13

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