Stimulators of acylated ghrelin secretion from Moringa oleifera leaves

被引：8

作者：

Ohta, Tomoe ^{[1
]}

Nakamura, Seikou ^{[1
]}

Nakashima, Souichi ^{[1
,2
]}

Shimakawa, Hiroyuki ^{[1
]}

Emi, Yuika ^{[1
]}

Matsumoto, Takahiro ^{[1
]}

Ogawa, Keiko ^{[1
]}

Fukaya, Masashi ^{[1
]}

Oda, Yoshimi ^{[1
,2
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] NTH Co Ltd, Shibuya Ku, 1-8-11 4F Sky Ebisu Bldg, Tokyo 1500013, Japan

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 21卷

关键词：

Moringa oleifera; Moringaside A; Moringamegastigmane A; Acylated ghrelin; CAMELLIA-SINENSIS; FLOWER BUDS; GLYCOSIDES; CONSTITUENTS; STOMACH; PEPTIDE; MICE;

D O I：

10.1016/j.phytol.2017.04.022

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new nitrogen-containing phenolic glycoside, moringaside A (1), and a new megastigmane glycoside, moringamegastigmane A (2), were isolated from the leaves of Moringa oleifera together with 16 known compounds. The chemical structures of the isolated compounds were elucidated on the basis of chemical and physicochemical evidence. To the best of our knowledge, there are few reports of compounds that effect acylated ghrelin secretion. Among the constituents of M. oleifera, niazirin (5) significantly stimulated the secretion of acylated ghrelin in vitro using rat primary gastric cells. This result suggests that 5 is a promising therapeutic agent for anorexia.

引用

页码：1 / 5

页数：5

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