Current Approaches and Future Directions of Gene Therapy in Alzheimer's Disease

被引：2
|
作者：
Stepanichev, M. Yu. [1 ]
机构：
[1] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia
来源：
NEUROCHEMICAL JOURNAL | 2011年 / 5卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
Alzheimer's disease; neurodegeneration; gene therapy; viral vector; nerve growth factor; NERVE GROWTH-FACTOR; AMYLOID-BETA; CHOLINERGIC NEURONS; LENTIVIRAL VECTORS; NEUROTROPHIC FACTOR; OXIDATIVE STRESS; MOUSE MODELS; IN-VITRO; ACETYLCHOLINE-RELEASE; TRANSGENE EXPRESSION;
D O I：
10.1134/S181971241103010X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We review the results of preclinical studies and clinical trials of gene therapy for the treatment of Alzheimer's disease. The possible application of gene-therapy approaches is discussed from the point of view of the pathogenesis of this disease. The problems and future directions of the clinical use of gene therapy for the treatment of Alzheimer's disease are discussed.
引用
收藏
页码：159 / 168
页数：10
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