Stupor from lamotrigine toxicity

被引：18
|
作者：
Sbei, M
Campellone, JV
机构：
[1] Cooper Hosp Univ Med Ctr, Dept Med, Div Neurol, Camden, NJ 08103 USA
[2] Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT 84132 USA
来源：
EPILEPSIA | 2001年 / 42卷 / 08期
关键词：
encephalopathy; lamotrigine; stupor; overdose; toxicity;
D O I：
10.1046/j.1528-1157.2001.0420081082.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose: To report that acute lamotrigine poisoning may result in severe encephalopathy. Methods: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. Results: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. Conclusions: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
引用
收藏
页码：1082 / 1083
页数：2
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