Diabetic patients lance themselves daily to obtain blood samples for glucose testing, and as reliable devices reach the market, many patients may prefer to test on body sites other than the finger to reduce pain. To date, healing of lancet wounds has not been well studied. This study included seven trials at four locations with 271 total subjects (59 non-diabetic, 212 diabetic) and evaluation of 2707 lancet wounds. A vacuum-lancet device pierced the skin to a depth of 0.4 to 2.1 mm with a 28- or 21-gauge lancet. Finger, forearm, abdomen, and thigh sites were characterized using videomicroscopy. The incidence of bruising and redness of the wound was determined by subject self-appraisal using a common photographic reproduction for comparison. Less erythema was measured on the fingertip than on the other body sites. For type 1 and type 2 diabetic subjects across a range of ages, erythema was resolved at 73 to 85 percent of the sites on the forearm on the third day after lancing. The incidence of bruising was higher for Female than for male diabetic subjects (6.5% vs. 2.5%). Resolution of the erythema from lancet wounds on the dorsal forearm was similar for a wide range of lancing depths (0.7-2.1 mm). The visual disappearance of wounds produced by different gauge lancets was similar. Resolution of erythema secondary to lancing the Forearm is typically complete in three days or less; however, considerable site-to-site and person-to-person variations are observed. Lancing body sites other than the finger is likely to become a common practice among diabetic patients.
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Signat Dermatol & Aesthet CarrolltonTexas, Carrollton, TX USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Champlain, Amanda H.
DiGiorgio, Catherine M.
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Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Boston Ctr Facial Rejuvenat, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
DiGiorgio, Catherine M.
Zurakowski, David
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Boston Childrens Hosp, Dept Anesthesiol, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Zurakowski, David
Sakamoto, Fernanda H.
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Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Harvard Med Sch, Dept Dermatol, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Sakamoto, Fernanda H.
Anderson, R. Rox
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机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
Harvard Med Sch, Dept Dermatol, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA
机构:
Meharry Med Coll, Sch Grad Studies, 1005 Dr DB Todd Jr Blvd Box 571, Nashville, TN 37208 USA
Nashville VA Med Ctr, Res Serv, Nashville, TN USAMeharry Med Coll, Sch Grad Studies, 1005 Dr DB Todd Jr Blvd Box 571, Nashville, TN 37208 USA
机构:
NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
Takeo, Makoto
Lee, Wendy
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机构:
NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
Lee, Wendy
Ito, Mayumi
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NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA
Ito, Mayumi
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE,
2015,
5
(01):
机构:
Juntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, Japan
Sato Pharmaceut Co Ltd, Drug Discovery Res Dept, Tokyo 1400011, JapanJuntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, Japan
Yasukawa, Ken
Okuno, Toshiaki
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机构:
Juntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, JapanJuntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, Japan
Okuno, Toshiaki
Yokomizo, Takehiko
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机构:
Juntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, JapanJuntendo Univ, Dept Biochem, Grad Sch Med, Tokyo 1138421, Japan
机构:
China Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R ChinaChina Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
Ren, Haiyue
Zhao, Feng
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机构:
China Med Univ, Dept Stem Cells & Regenerat Med, Shenyang Key Lab Stem Cell & Regenerat Med, Shenyang 110013, Liaoning, Peoples R ChinaChina Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
Zhao, Feng
Zhang, Qiqi
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机构:
China Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R ChinaChina Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
Zhang, Qiqi
Huang, Xing
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机构:
China Med Univ, Dept Gen Surg, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R ChinaChina Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
Huang, Xing
Wang, Zhe
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China Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R ChinaChina Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China