SUBPOPULATION OF LYMPHOCYTES CD4+ AND CD8+ IN PERIPHERAL BLOOD OF SHEEP WITH ZEARALENONE MYCOTOXICOSIS

被引：0

作者：

Kostro, Krzysztof ^{[1
,2
]}

Gajecka, Magdalena ^{[3
]}

Lisiecka, Urszula ^{[1
,2
]}

Majer-Dziedzic, Barbara ^{[4
]}

Obremski, Kazimierz ^{[3
]}

Zielonka, Lukasz ^{[3
]}

Gajecki, Maciej ^{[3
]}

机构：

[1] Univ Life Sci Lublin, Fac Vet Med, Dept Epizootiol, PL-20612 Lublin, Poland

[2] Univ Life Sci Lublin, Fac Vet Med, Clin Infect Dis, PL-20612 Lublin, Poland

[3] Univ Warmia & Mazury, Fac Vet Med, Chair Vet Prevent & Feed Hyg, PL-10718 Olsztyn, Poland

[4] Univ Life Sci Lublin, Fac Vet Med, Inst Biol Bases Anim Dis, Subdept Vet Microbiol, PL-20033 Lublin, Poland

来源：

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2011年 / 55卷 / 02期

关键词：

sheep; zearalenone; mycotoxicosis; lymphocytes; immunosuppression; flow cytometry; METABOLISM; ALPHA; BETA; DON;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In sheep raised in chamber system and fed concentrate fodder containing high dose of zearalenone and its metabolite (alpha-zearalenol), the clinical course of zearalenonosis was diagnosed. Control animals were kept on grazing-land from the spring to the late autumn, and only in winter time they were fed shredded wheat with the lowest concentration of zearalenone. These sheep showed no clinical symptoms of the mycotoxicosis. Zearalenone and alpha-zearalenol cause immunosuppression, which means that lymphocyte T CD4+ and lymphocyte T CD8+ percentages decline and CD4/CD8 ratio increases when compared with control animals. Zearalenone mycotoxin suppression effect modulates cellular immunological response, which is essential in suppression of post-vaccination immunity and infectious diseases development despite applying normal specific immunoprophylaxis.

引用

页码：241 / 246

页数：6

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