Synthesis, characterization, and biological activity of transition metals complexes with mefenamic acid (NSAIDs)

被引：3

作者：

Ramzan, S. ^{[1
]}

Saleem, S. ^{[2
]}

Mirza, B. ^{[2
]}

Ali, S. ^{[1
]}

Ahmed, F. ^{[3
]}

Shahzadi, S. ^{[1
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan

[3] NESCOM, Islamabad, Pakistan

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2015年 / 85卷 / 07期

关键词：

mefenamic acid; transition metals; complexes; IR; UV-Vis; conductance; antibacterial; antifungal; antitumor; antioxidant activity; DNA interaction; NONSTEROIDAL ANTIINFLAMMATORY DRUGS;

D O I：

10.1134/S1070363215070282

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of transition metal complexes have been synthesized with [(2,3-dimethylphenyl)-amino]benzoic acid (Mefenamic acid) in 1 : 1/1 : 2 M : L ratio. The complexes have been characterized by elemental analysis, FT-IR and UV-Vis spectroscopy. Antifungal, antibacterial, antitumor, antioxidant (DPPH, H2O2 induced DNA damage) activity of the complexes and DNA interaction with the complexes were studied. The results revealed that the ligand and most of synthesized compounds did not demonstrate significant antibacterial activity unlike [Ni(Mef)(H2O)Cl] that exhibited pronounced activity against F. Solani. Antitumor activity of the products was higher than that of the free ligand.

引用

页码：1745 / 1751

页数：7

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