Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia

被引：7
|
作者：
Del Casale, A. [1 ,2 ,3 ]
Rossi-Espagnet, M. C. [4 ,5 ,6 ]
Napolitano, A. [4 ]
Lucignani, M. [4 ]
Bonanni, L. [3 ,5 ]
Kotzalidis, G. D. [3 ,5 ]
Buscajoni, A. [3 ,5 ]
Manelfi, L. [3 ,5 ]
Perrone, V [5 ,6 ]
Gualtieri, I [3 ,5 ]
Brugnoli, R. [3 ,5 ]
De Pisa, E. [3 ,5 ]
Girardi, P. [3 ,5 ]
Romano, A. [5 ,6 ]
Ferracuti, S. [7 ,8 ]
Bozzao, A. [5 ,6 ]
Pompili, M. [3 ,5 ]
机构：
[1] Sapienza Univ, Fac Med & Psychol, Dept Dynam & Clin Psychol, Rome, Italy
[2] Sapienza Univ, Fac Med & Psychol, Hlth Studies, Rome, Italy
[3] St Andrea Univ Hosp, Unit Psychiat, Via Grottarossa 1035-1039, I-00189 Rome, Italy
[4] Sci Inst Res Hospitalizat & Hlth Care IRCCS Bambi, Imaging Dept, Neuroradiol Unit, Rome, Italy
[5] Sapienza Univ, Fac Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NESMOS, Rome, Italy
[6] St Andrea Univ Hosp, Unit Neuroradiol, Rome, Italy
[7] Sapienza Univ, Fac Med & Dent, Dept Human Neurosci, Rome, Italy
[8] St Andrea Univ Hosp, Unit Risk Management, Rome, Italy
来源：
ARCHIVES ITALIENNES DE BIOLOGIE | 2021年 / 159卷 / 01期
关键词：
Schizophrenia; First-Episode Psychoses; Multi-episode Schizophrenia; Cortical Thickness; Gyrification Index; SUPERIOR TEMPORAL GYRUS; RISK-FACTOR MODEL; 1ST EPISODE; STRUCTURAL ALTERATIONS; FOLDING ABNORMALITIES; SUBCORTICAL VOLUMES; ONSET SCHIZOPHRENIA; POSITIVE SYMPTOMS; COGNITIVE INSIGHT; BRAIN-DEVELOPMENT;
D O I：
10.12871/00039829202111
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.
引用
收藏
页码：3 / 20
页数：18
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