Cross-Reactive Antibody Responses to Novel H5Nx Influenza Viruses Following Homologous and Heterologous Prime-Boost Vaccination with a Prepandemic Stockpiled A(H5N1) Vaccine in Humans

被引：16
|
作者：
Levine, Min Z. [1 ]
Holiday, Crystal [1 ]
Liu, Feng [1 ]
Jefferson, Stacie [1 ]
Gillis, Eric [1 ]
Bellamy, Abbie R. [2 ]
Tumpey, Terrence [1 ]
Katz, Jacqueline M. [1 ]
机构：
[1] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE, Atlanta, GA 30329 USA
[2] Emmes Corp, Stat & Data Coordinating Ctr, Rockville, MD USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2017年 / 216卷
关键词：
highly pathogenic avian influenza viruses; pre-pandemic stockpile; antibody responses; UNITED-STATES; IMMUNOGENICITY; SAFETY;
D O I：
10.1093/infdis/jix001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses.
引用
收藏
页码：S555 / S559
页数：5
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