Colloids containing gadolinium-capped gold nanoparticles as high relaxivity dual-modality contrast agents for CT and MRI

被引：15
|
作者：
Zeng, ChengCai [1 ]
Shi, XiaoNi [1 ]
Wu, Bo [1 ]
Zhang, Dong [1 ]
Zhang, WeiLu [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Zhejiang, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 123卷
关键词：
Colloid; Contrast agents; Gold nanoparticles; MRI/CT dual-modality; Gadolinium; STABILITY; NANORODS;
D O I：
10.1016/j.colsurfb.2014.09.007
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A type of novel macromolecular colloid was prepared from gadolinium-based poly(L-succinimide) and gold nanoparticles (GNPs) with Au-S covalent bonds. The colloid displayed improved stability in aqueous media and regular arrays in partial region. Moreover, these materials enhanced the contrast 9 times more than that of the corresponding uncoated Au compound when the Au mass content was only 0.15%. Therefore, these materials might have potential as dual-modality contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT). (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：130 / 135
页数：6
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