Prognostic significance of β-catenin expression in patients with ovarian cancer: A meta-analysis

Aim The purpose of this study was to evaluate the impact of beta-catenin immunohistochemical expression on the prognostic of ovarian cancer (OC) for that beta-catenin could be responsible for the development and progress of OC. Methods: We searched various databases to identify eligible studies, and Review Managers 5.2 software was fulfilled in the meta-analysis. Results: A total of 11 studies were defined and composed in 1858 cases. beta-catenin expression was significantly correlated with poor overall survival (OS) in OC patients (HR: 2.48, 95% CI: 1.38-4.47, P = 0.003), and showed a significant degree of heterogeneity (I-2 = 83%, P < 0.00001). Subgroup analysis indicated that accumulation in the nucleus and/or cytoplasm, rather than membrane, considerably influences the survival of OC patients independently. Conclusion: Nucleus and/or cytoplasma of beta-catenin expression might be associated with tumor progression and could be a possible potential predictive factor of poor prognosis in OC patients.