Resident intimal dendritic cells and the initiation of atherosclerosis

被引：44
|
作者：
Cybulsky, Myron I. [1 ,2 ]
Jongstra-Bilen, Jenny [1 ,2 ,3 ]
机构：
[1] Univ Toronto, Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada
[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada
来源：
CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期
基金：
加拿大健康研究院;
关键词：
dendritic cells; endothelium; gene expression; hemodynamics; monocytes; NF-KAPPA-B; APOE-DEFICIENT MOUSE; IN-VIVO DEPLETION; MONOCYTE SUBSETS; ADHESION MOLECULE-1; SCAVENGER-RECEPTORS; ENDOTHELIAL-CELLS; LESION FORMATION; ARTERIAL INTIMA; DISTURBED FLOW;
D O I：
10.1097/MOL.0b013e32833ded96
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The unique features of the arterial intima at atherosclerosis-susceptible sites do not lead to disease under normal physiological conditions, but this intimal environment promotes the initiation of atherogenesis upon induction of systemic risk factors such as hypercholesterolemia.
引用
收藏
页码：397 / 403
页数：7
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