Improved Survival in Liver Transplant Recipients Receiving Prolonged-Release Tacrolimus in the European Liver Transplant Registry

被引：66

作者：

Adam, R. ^{[1
]}

Karam, V. ^{[1
]}

Delvart, V. ^{[1
]}

Trunecka, P. ^{[2
]}

Samuel, D. ^{[1
]}

Bechstein, W. O. ^{[3
]}

Nemec, P. ^{[4
]}

Tisone, G. ^{[5
]}

Klempnauer, J. ^{[6
]}

Rossi, M. ^{[7
]}

Rummo, O. O. ^{[8
]}

Dokmak, S. ^{[9
]}

Krawczyk, M. ^{[10
]}

Pratschke, J. ^{[11
]}

Kollmar, O. ^{[12
,13
]}

Boudjema, K. ^{[14
]}

Colledan, M. ^{[15
]}

Ericzon, B. G. ^{[16
]}

Mantion, G. ^{[17
]}

Baccarani, U. ^{[18
]}

Neuhaus, P. ^{[19
]}

Paul, A. ^{[20
]}

Bachellier, P. ^{[21
]}

Zamboni, F. ^{[22
]}

Hanvesakul, R. ^{[23
]}

Muiesan, P. ^{[24
]}

机构：

[1] Univ Paris 11, Paul Brousse Hosp, AP HP, Hepato Biliary Ctr,Inserm U 776, Villejuif, France

[2] Inst Clin & Expt Med IKEM, Transplantctr, Prague, Czech Republic

[3] Goethe Univ Hosp & Clin, Dept Gen & Visceral Surg, Frankfurt, Germany

[4] Ctr Cardiovasc Surg & Transplantat, Brno, Czech Republic

[5] Univ Roma Tor Vergata, Tor Vergata Polyclin, Liver Transplant Unit, Rome, Italy

[6] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Hannover, Germany

[7] Umberto 1 Policlin Rome, Organ Transplant Unit Paride Stefanini, Dept Gen Surg, Rome, Italy

[8] Republican Sci & Pract Ctr RSPC Organ & Tissue Tr, Minsk, BELARUS

[9] Beaujon Hosp, AP HP, Dept HPB Surg & Liver Transplantat, Clichy, France

[10] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland

[11] Med Univ Innsbruck, Dept Gen & Transplant Surg, A-6020 Innsbruck, Austria

[12] Univ Med Ctr Gottingen, Dept Gen Visceral & Pediat Surg, Gottingen, Germany

[13] Univ Saarland, Dept Gen Visceral Vasc & Pediat Surg, Homburg, Germany

[14] Univ Hosp Rennes, Pontchaillou Hosp, Dept Visceral Surg, Rennes, France

[15] Pope John XXIII Hosp, Dept Surg, Bergamo, Italy

[16] Karolinska Inst, Div Transplantat Surg, Stockholm, Sweden

[17] Univ Franche Comte, Univ Hosp Besancon, Dept Visceral Surg, F-25030 Besancon, France

[18] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy

[19] Charite Campus Virchow Klinikum CVK, Dept Gen Visceral & Transplantat Surg, Berlin, Germany

[20] Univ Hosp Essen, Dept Gen & Transplant Surg, Essen, Germany

[21] Univ Hosp Strasbourg, Hosp Hautepierre, Dept Surg, Strasbourg, France

[22] Hosp G Brotzu, Dept Gen Surg & Transplantat, Cagliari, Italy

[23] Astellas Pharma Europe, EU Med Affairs, Chertsey, Surrey, England

[24] Queen Elizabeth Hosp Birmingham, Liver & HPB Unit, Birmingham, W Midlands, England

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 05期

关键词：

ONCE-DAILY TACROLIMUS; TWICE-DAILY TACROLIMUS; RANDOMIZED CONTROLLED-TRIAL; RENAL-FUNCTION; ADHERENCE; IMMUNOSUPPRESSION; CONVERSION; MEDICATION; MORTALITY; EFFICACY;

D O I：

10.1111/ajt.13171

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This study was a retrospective analysis of the European Liver Transplant Registry (ELTR) performed to compare long-term outcomes with prolonged-release tacrolimus versus tacrolimus BD in liver transplantation (January 2008-December 2012). Clinical efficacy measures included univariate and multivariate analyses of risk factors influencing graft and patient survival at 3 years posttransplant. Efficacy measures were repeated using propensity score-matching for baseline demographics. Patients with <1 month of follow-up were excluded from the analyses. In total, 4367 patients (prolonged-release tacrolimus: n=528; BD: n=3839) from 21 European centers were included. Tacrolimus BD treatment was significantly associated with inferior graft (risk ratio: 1.81; p=0.001) and patient survival (risk ratio: 1.72; p=0.004) in multivariate analyses. Similar analyses performed on the propensity score-matched patients confirmed the significant survival advantages observed in the prolonged-release tacrolimus- versus tacrolimus BD-treated group. This large retrospective analysis from the ELTR identified significant improvements in long-term graft and patient survival in patients treated with prolonged-release tacrolimus versus tacrolimus BD in primary liver transplant recipients over 3 years of treatment. However, as with any retrospective registry evaluation, there are a number of limitations that should be considered when interpreting these data.

引用

页码：1267 / 1282

页数：16

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